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None of the study participants had epicardial coronary artery disease (as required by the enrollment criteria); 7 of 11 patients underwent coronary angiography, which showed no significant coronary stenosis, and 4 of 11 patients underwent noninvasive stress testing, which showed no evidence of myocardial ischemia.

The ROLE (Ranolazine Open Label Experience) program included 746 patients who completed the MARISA and CARISA trials and consented to participate in an open-label, 6-year follow-on extension.

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Monotherapy Assessment of Ranolazine In Stable Angina (MARISA), 4 Combination Assessment of Ranolazine In Stable Angina (CARISA), 5 and Efficacy of Ranolazine In Chronic Angina (ERICA) 6 established the role of ranolazine in the management of chronic stable angina.

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Most myocardial infarctions are caused by clots dislodged from atherosclerotic plaque with or without vasospasms (i.

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All hemodynamic pressure measurements were made at end expiration and in duplicate using a standardized measurement protocol by a physician blinded to all clinical data.

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