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These noncontraceptive benefits include menstrual cycle control, decreased menstrual blood loss, reduced dysmenorrhea, prevention of ovarian cyst formation, decreased ectopic pregnancy risk, protection against endometrial, ovarian and colon cancer, decreased risk of pelvic inflammatory disease, less benign breast disease, treatment of acne, and increased bone mass.

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While observing comparable clinical outcomes, the use of E 2 might offer several practical advantages compared to OCP: (1) Because E 2 pretreatment is started in the midluteal phase, preparation for a programmed stimulation with a GnRH antagonist protocol can be scheduled in the same cycle even if the patient expresses a desire to start treatment after the early follicular phase.

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CPA, cyroterone acetate; E 2V, estradiol valerate; FSH, follicle-stimulating hormone; LH, luteinizing hormone; MRS, Menopause Rating Scale; MENQOL, Menopause-Specific Quality of Life.

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